A while back one of my best friends lost a parent and it was really hard on them. Losing a parent is one of the most difficult things that someone can go through. I was unable to feel what my friend felt, but I do know losing someone hurts. Things happen and it sucks.
An idea for a case of undeserved misfortune is the main character of a movie meeting up with a family member and the main character is trying to convince the family member to stay, but they have work and leave. Something happens to the family member on their way home and the main character is convinced that it is his/her fault. The main character struggles through the movie to persuade his/herself that they really aren't to blame for their family member's death.